The bus operator is advising customers of route alterations and bus stop changes on Thursday night as the Welsh national side take on Spain at the Principality Stadium.
From 5.30pm until the last bus, road closures will be in place across the city centre as thousands of fans flock to the stadium for a 7.45pm kick off.
During the sporting fixture, services, 8, 9, and 9A to Cardiff Bay and the Sports Village, along with the 13 to the Sports Village, 54 to Channel View and X45 to Asda Cardiff Bay, will all depart from Hayes Bridge Road, alongside John Lewis.
Route alterations will see services 1 and 2 start from Canal Street and not serve the rear Central Railway Station after 5.30pm. While the Baycar, service 6 will start from Customhouse Street and will not travel via the rear of Central Station.
Services 92, 93 and 94 will depart from Customhouse Street until 7pm and then from Tudor Street after 7pm. While the 8, 9, and 9A to Heath Hospital, along with the 44, 45, 49, 50, 51, 52, 57, 58, 61 to Pengam Green, X45 to St Mellons and the X59 Cardiff East Park & Ride will all start from Churchill Way.
Other bus stop changes include the 13 to Drope, along with the 15, 17, 18, 25, and 61 to Pentrebane, 63, 64, 65, 66, 95 towards Barry, 95A, 95B, 95C, 96, 96A and the X91 which will all start from Tudor Street. While the 21, 23, 24, 27, 28, 28A, 28B, 30, 35, 53, and 54 to Cyncoed, 86 and 95 to Heath Hospital will start from Greyfriars Road.
The night buses will be unaffected by the route and bus stop changes.
Cardiff Bus commercial manager Gareth Stevens said it was set to be an exciting event and urged fans to check all travel changes.
“To accommodate both fans, and customers across the city during the road closures, we’ve made some service alterations and bus stop changes which will come into force from 5.30pm on Thursday.
“We’d urge all those travelling around the city that evening, either for the event or not, to check for any route alterations and plan their travel accordingly. We have attempted to keep disruption to a minimum to ensure our customers can continue to travel throughout the city during the evening.
“We’d like to wish Wales good luck against Spain and hope everyone enjoys the game. We’d also like to remind anyone with queries about travel to visit our website cardiffbus.com or our Twitter and Facebook pages for up to date travel information.”